Zinc finger, ZPR1
Description
| PFAM: | The zinc-finger protein ZPR1 is localised to the cytoplasm in quiescent cells; in proliferating cells treated with EGF or with other mitogens it accumulates in the nucleolus. Upon stimulation by EGF, ZPR1 directly binds the eukaryotic translation elongation factor-1alpha (eEF-1alpha) to form ZPR1/eEF-1alpha complexes. These move into the nucleus, localising particularly at the nucleolus. ZPR1 is thought to be involved in pre-ribosomal RNA expression. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded beta helix with a helical hairpin insertion. |
References:
| 1) | Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503 PubMed |
| 2) | Gangwani, L1; Mikrut, M; Galcheva-Gargova, Z; Davis, RJ. 1998. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. J Cell Biol 143(6):1471-84 PubMed |
| 3) | Galcheva-Gargova, Z; Gangwani, L; Konstantinov, KN; Mikrut, M; Theroux, SJ; Enoch, T; Davis RJ. 1998. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Mol Biol Cell 9(10):2963-71 PubMed |
Summary
| Name: | Zinc finger, ZPR1 |
|---|---|
| Class: | TR |
| Number of species containing the TAP: | 122 |
| Number of available proteins: | 184 |
The colour code corresponds to the rules for the domains:
should be contained
should not be contained
should not be contained
Domain rules:
(Domain names are clickable)
Phylogenetic tree for Archeaplastida:
No tree was calculated yet.
TAP distribution:
The following table shows the distribution of Zinc finger, ZPR1 over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.
| Minimum | Maximum | Average | Median | Standard deviation |
|---|---|---|---|---|
| 0 | 7 | 1.51 | 1 | 1.08 |